The correlation between the expression of differentiated embryo-chondrocyte expressed gene l and oral squamous cell carcinoma

Eur J Med Res. 2014 Apr 23;19(1):21. doi: 10.1186/2047-783X-19-21.

Abstract

Background: This study aims to explore the correlation between expression of differentiated embryo-chondrocyte expressed gene l (DEC1) and oral squamous cell carcinoma (OSCC), which could provide the reference for treatment and prognosis assessment of OSCC.

Methods: The expression of DEC1 in tissues from 56 primary OSCC patients and 20 normal oral mucosa samples were detected using real-time polymerase chain reaction and immunohistochemical methods, respectively.

Results: The results showed that the positive expression rate of DEC1 in the OSCC group was significantly higher than that in the normal group (P <0.05); further, the expression of DEC1 in different OSCC groups was statistically significant (P <0.05). The expression of DEC1 in the 1-year recurrence OSCC group was significantly higher than other groups. The expression of DEC1 in the 3-years no recurrence OSCC group was the lowest.

Conclusions: The expression of DEC1 was associated with the incidence of OSCC and there was a negative correlation between the expression of DEC1 and the prognosis of OSCC.

MeSH terms

  • Adult
  • Biomarkers, Tumor / analysis*
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / metabolism*
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Mouth Neoplasms / genetics
  • Mouth Neoplasms / metabolism*
  • Neoplasm Recurrence, Local / metabolism
  • Real-Time Polymerase Chain Reaction
  • Tumor Suppressor Proteins / analysis
  • Tumor Suppressor Proteins / biosynthesis*

Substances

  • Biomarkers, Tumor
  • DELEC1 protein, human
  • Tumor Suppressor Proteins