Discovering up-regulated VEGF-C expression in swine umbilical vein endothelial cells by classical swine fever virus Shimen

Pengbo Ning; Yanming Zhang; Kangkang Guo; Ru Chen; Wulong Liang; Zhi Lin; Helin Li

doi:10.1186/1297-9716-45-48

Discovering up-regulated VEGF-C expression in swine umbilical vein endothelial cells by classical swine fever virus Shimen

Vet Res. 2014 Apr 23;45(1):48. doi: 10.1186/1297-9716-45-48.

Authors

Pengbo Ning, Yanming Zhang¹, Kangkang Guo, Ru Chen, Wulong Liang, Zhi Lin, Helin Li

Affiliation

¹ College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China. zhangym@nwsuaf.edu.cn.

Abstract

Infection of domestic swine with the highly virulent Shimen strain of classical swine fever virus causes hemorrhagic lymphadenitis and diffuse hemorrhaging in infected swine. We analyzed patterns of gene expression for CSFV Shimen in swine umbilical vein endothelial cells (SUVECs). Transcription of the vascular endothelial growth factor (VEGF) C gene (VEGF-C) and translation of the corresponding protein were significantly up-regulated in SUVECs. Our findings suggest that VEGF-C is involved in mechanisms of acute infection caused by virulent strains of CSFV.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Classical Swine Fever / genetics*
Classical Swine Fever / virology
Classical Swine Fever Virus / genetics
Classical Swine Fever Virus / pathogenicity*
Classical Swine Fever Virus / physiology*
Endothelial Cells / metabolism
Gene Expression Profiling / veterinary
Gene Expression Regulation, Viral
Swine
Swine Diseases / genetics*
Swine Diseases / virology
Umbilical Veins / metabolism
Umbilical Veins / virology
Up-Regulation
Vascular Endothelial Growth Factor C / genetics*
Vascular Endothelial Growth Factor C / metabolism
Virulence

Substances

Vascular Endothelial Growth Factor C