Distant metastatic disease manifestations in infiltrating lobular carcinoma of the breast

AJR Am J Roentgenol. 2014 May;202(5):1140-8. doi: 10.2214/AJR.13.11156.


Objective: This article reviews unusual distant metastatic patterns of infiltrating lobular carcinoma (ILC) of the breast.

Conclusion: ILC of the breast tends to spread to the gastrointestinal tract, genitourinary tract, peritoneum, retroperitoneum, and leptomeninges in addition to common visceral sites such as the liver, bone, and lung. Knowledge of these unusual metastatic manifestations and disease patterns may aid in differentiating distant metastatic disease from secondary primary cancers and help plan appropriate therapy.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / pathology*
  • Carcinoma, Lobular / secondary*
  • Female
  • Gastrointestinal Neoplasms / secondary
  • Humans
  • Urogenital Neoplasms / secondary