Involuntary weight loss remains an important and challenging clinical problem, with a high degree of morbidity and mortality. Because of the frequency of finding a serious underlying diagnosis, clinicians must be thorough in assessment, keeping in mind a broad range of possible causes. Although prediction scores exist, they have not been broadly validated; therefore, clinical judgment remains ever essential.
Keywords: Diagnosis; Etiology; Involuntary weight loss; Malignancy; Prognosis; Unexplained weight loss; Unintended weight loss; Unintentional weight loss.
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