Panax red ginseng extract regulates energy expenditures by modulating PKA dependent lipid mobilization in adipose tissue

Biochem Biophys Res Commun. 2014 May 16;447(4):644-8. doi: 10.1016/j.bbrc.2014.04.056. Epub 2014 Apr 20.


Regulation of balance between lipid accumulation and energy consumption is a critical step for the maintenance of energy homeostasis. Here, we show that Panax red ginseng extract treatments increased energy expenditures and prevented mice from diet induced obesity. Panax red ginseng extracts strongly activated Hormone Specific Lipase (HSL) via Protein Kinase A (PKA). Since activation of HSL induces lipolysis in WAT and fatty acid oxidation in brown adipose tissue (BAT), these results suggest that Panax red ginseng extracts reduce HFD induced obesity by regulating lipid mobilization.

Keywords: Adipose tissue; Energy expenditures; Obesity; Panax ginseng; Protein Kinase A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AMP-Activated Protein Kinases / metabolism
  • Adipose Tissue / drug effects*
  • Adipose Tissue / metabolism*
  • Adipose Tissue, Brown / drug effects
  • Adipose Tissue, Brown / metabolism
  • Adipose Tissue, White / drug effects
  • Adipose Tissue, White / metabolism
  • Animals
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Diet, High-Fat
  • Energy Metabolism / drug effects*
  • Lipid Mobilization / drug effects*
  • Mice
  • Mice, Inbred C57BL
  • Obesity / metabolism
  • Obesity / prevention & control
  • Panax*
  • Plant Extracts / pharmacology


  • Plant Extracts
  • Cyclic AMP-Dependent Protein Kinases
  • AMP-Activated Protein Kinases