Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases

Curr Opin Neurobiol. 2014 Aug;27:158-64. doi: 10.1016/j.conb.2014.03.001. Epub 2014 Apr 22.


Signaling pathways and cellular processes that regulate neural development are used post-developmentally for proper function and maintenance of the nervous system. Genes that have been studied in the context of the development of Drosophila peripheral nervous system (PNS) and neuromuscular junction (NMJ) have been identified as players in the pathogenesis of human neurodegenerative diseases, including spinocerebellar ataxia, amyotrophic lateral sclerosis, and spinal muscular atrophy. Hence, by unraveling the molecular mechanisms that underlie proneural induction, cell fate determination, axonal targeting, dendritic branching, and synapse formation in Drosophila, novel features related to these disorders have been revealed. In this review, we summarize and discuss how studies of Drosophila PNS and NMJ development have provided guidance in experimental approaches for these diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytoskeletal Proteins / metabolism
  • Disease Models, Animal
  • Drosophila
  • Humans
  • MicroRNAs / physiology
  • Muscle Proteins / metabolism
  • Neurodegenerative Diseases / genetics
  • Neurodegenerative Diseases / metabolism
  • Neurodegenerative Diseases / pathology
  • Neurodegenerative Diseases / physiopathology*
  • Neuromuscular Junction / pathology
  • Peripheral Nervous System / embryology
  • Peripheral Nervous System / growth & development*
  • Signal Transduction / physiology*


  • Cytoskeletal Proteins
  • MicroRNAs
  • Muscle Proteins
  • Smooth muscle protein, human