Effects of Aloe vera cream on chronic anal fissure pain, wound healing and hemorrhaging upon defection: a prospective double blind clinical trial

Eur Rev Med Pharmacol Sci. 2014;18(7):1078-84.


Aloe vera is a medicinal plant that promotes wound healing in burn injuries. A prospective clinical trial was conducted to evaluate the effects of a topical cream containing 0.5% Aloe vera juice powder in the treatment of chronic anal fissures. The aloe cream was applied by the patients to the wound site 3 times per day for 6 weeks following the instructions of a physician. Pain was assessed with a visual analog scale before treatment and at the end of each week of treatment. Wound healing and the amount and severity of bleeding were examined and evaluated before and at the end of each week of treatment. There were statistically significant differences in chronic anal fissure pain, hemorrhaging upon defection and wound healing before and at the end of the first week of treatment also in comparison with control group (p < 0.0001). In this study, a topical cream containing aloe vera juice was an effective treatment for chronic anal fissures. This is a promising result indicating that further comparative studies are justified.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aloe*
  • Defecation
  • Double-Blind Method
  • Fissure in Ano / drug therapy*
  • Hemorrhage / drug therapy*
  • Humans
  • Middle Aged
  • Pain / drug therapy*
  • Pain Measurement
  • Phytotherapy*
  • Plant Leaves
  • Plant Preparations / therapeutic use*
  • Wound Healing / drug effects
  • Young Adult


  • Plant Preparations