Evaluation of inner retinal layers in eyes with temporal hemianopic visual loss from chiasmal compression using optical coherence tomography

Invest Ophthalmol Vis Sci. 2014 Apr 24;55(5):3328-36. doi: 10.1167/iovs.14-14118.


Purpose: We measured macular inner retinal layer thicknesses using frequency-domain optical coherence tomography (fd-OCT) and correlated these measures with visual field (VF) in eyes with temporal hemianopia from chiasmal compression and band atrophy (BA) of the optic nerve.

Methods: Macular fd-OCT scans and VFs were obtained from 33 eyes of 33 patients with temporal hemianopia and 36 control eyes. The macular retinal nerve fiber layer (mRNFL), combined retinal ganglion cell and inner plexiform layers (RGCL+), and the inner nuclear layer (INL) were segmented. Measurements were averaged for each macula quadrant. Scans were assessed qualitatively for microcysts in the INL. The VF was estimated from the central 16 test points. The two groups were compared. Correlations between VF and OCT measurements were assessed.

Results: The mRNFL, RGCL+, and total retinal (TR) macular thickness measurements were significantly smaller in BA eyes than controls. In the nasal quadrants, INL measurements were significantly greater in BA eyes than controls. The mRNFL and RGCL+ measurements had greater discrimination ability than TR measurements in the temporal quadrants. A significant correlation was found between most OCT parameters and their corresponding VF parameters. The strongest association was observed between RNFL and RGCL+ thickness, and VF loss in the corresponding area. The INL microcysts were found in seven eyes with BA, but not in controls.

Conclusions: Band atrophy leads to mRNFL and RGCL+ thinning, and INL thickening, and mRNFL and RGCL+ measurements are correlated strongly with VF loss. Segmented macular thickness measurements may be useful for quantifying neuronal loss in chiasmal compression.

Keywords: band atrophy; inner nuclear layer; macular thickness; optical coherence tomography; retinal ganglion cell layer thickness; retinal nerve fiber layer.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Constriction, Pathologic
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Hemianopsia / diagnosis*
  • Hemianopsia / etiology
  • Hemianopsia / physiopathology
  • Humans
  • Macula Lutea / pathology*
  • Male
  • Middle Aged
  • Optic Chiasm / pathology*
  • Optic Nerve Diseases / complications
  • Optic Nerve Diseases / diagnosis*
  • Optic Nerve Diseases / physiopathology
  • Prospective Studies
  • Retinal Ganglion Cells / pathology*
  • Tomography, Optical Coherence / methods*
  • Visual Field Tests
  • Visual Fields / physiology*
  • Young Adult