First-trimester maternal factors and biomarker screening for preeclampsia

Prenat Diagn. 2014 Jul;34(7):618-27. doi: 10.1002/pd.4397. Epub 2014 May 21.


Preeclampsia (PE), which affects about 2% of pregnancies, is a major cause of maternal and perinatal morbidity and mortality. PE can be subdivided into early onset PE with delivery <34 weeks' gestation and late onset PE with delivery ≥34 weeks. Early onset PE is associated with a higher incidence of adverse outcome. This review illustrates that effective screening for the development of early onset PE can be provided in the first-trimester of pregnancy. Screening by a combination of maternal risk factors, mean arterial pressure, uterine artery Doppler, maternal serum pregnancy-associated plasma protein-A and placental growth factor can identify about 95% of cases of early onset PE for a false-positive rate of 10%.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / blood*
  • Female
  • Humans
  • Mothers
  • Pre-Eclampsia / blood
  • Pre-Eclampsia / diagnosis*
  • Pre-Eclampsia / etiology*
  • Pregnancy
  • Pregnancy Trimester, First / blood*
  • Prenatal Diagnosis* / methods
  • Reproductive History
  • Risk Factors


  • Biomarkers