N-cadherin/catenin Complex as a Master Regulator of Intercalated Disc Function

Cell Commun Adhes. 2014 Jun;21(3):169-79. doi: 10.3109/15419061.2014.908853. Epub 2014 Apr 28.

Abstract

Intercellular adhesive junctions are essential for maintaining the physical integrity of tissues; this is particularly true for the heart that is under constant mechanical load. The correct functionality of the heart is dependent on the electrical and mechanical coordination of its constituent cardiomyocytes. The intercalated disc (ID) structure located at the termini of the rod-shaped adult cardiomyocyte contains various junctional proteins responsible for the integration of structural information and cell-cell communication. According to the classical description, the ID consists of three distinct junctional complexes: adherens junction (AJ), desmosome (Des), and gap junction (GJ) that work together to mediate mechanical and electrical coupling of cardiomyocytes. However, recent morphological and molecular studies indicate that AJ and Des components are capable of mixing together resulting in a "hybrid adhering junction" or "area composita." This review summarizes recent progress in understanding the in vivo function(s) of AJ components in cardiac homeostasis and disease.

Keywords: N-cadherin; adherens junction; arrhythmogenic cardiomyopathy; catenin; desmosome.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adherens Junctions / metabolism
  • Animals
  • Cadherins / metabolism*
  • Catenins / metabolism*
  • Humans
  • Myocytes, Cardiac / cytology*
  • Myocytes, Cardiac / metabolism*

Substances

  • Cadherins
  • Catenins