Inhibitory actions of procaterol, a beta-2 stimulant, on substance P-induced cough in normal subjects during upper respiratory tract infection

Tohoku J Exp Med. 1989 May;158(1):105-6. doi: 10.1620/tjem.158.105.


We studied substance P (SP)-induced cough in normal subjects without and with colds, and the effects of orally administered procaterol on SP-induced cough in normal subjects with colds. SP aerosols caused cough at a concentration of approximately 10(-15) M in subjects with colds whereas it did not cause cough at a concentration of up to 10(-5) M in subjects without colds. Procaterol (50 micrograms) completely inhibited SP-induced cough in normal subjects with colds. These results suggest that cough response to SP remarkably increases during colds and that beta-2 stimulant may be a useful tool for treatment of cough during colds in normal subjects.

MeSH terms

  • Adrenergic beta-Agonists / pharmacology*
  • Adult
  • Cough / chemically induced
  • Cough / physiopathology*
  • Ethanolamines / pharmacology*
  • Female
  • Forced Expiratory Volume
  • Humans
  • Male
  • Procaterol
  • Respiratory Tract Infections / physiopathology*
  • Substance P*


  • Adrenergic beta-Agonists
  • Ethanolamines
  • Substance P
  • Procaterol