RNA epigenetics

Transl Res. 2015 Jan;165(1):28-35. doi: 10.1016/j.trsl.2014.04.003. Epub 2014 Apr 8.

Abstract

Mammalian messenger RNA (mRNA) and long noncoding RNA (lncRNA) contain tens of thousands of posttranscriptional chemical modifications. Among these, the N(6)-methyl-adenosine (m(6)A) modification is the most abundant and can be removed by specific mammalian enzymes. m(6)A modification is recognized by families of RNA binding proteins that affect many aspects of mRNA function. mRNA/lncRNA modification represents another layer of epigenetic regulation of gene expression, analogous to DNA methylation and histone modification.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adenosine / analogs & derivatives
  • Adenosine / chemistry
  • Adenosine / metabolism
  • Animals
  • Epigenesis, Genetic*
  • Humans
  • Methyltransferases / genetics
  • Methyltransferases / metabolism
  • Mice
  • RNA / chemistry
  • RNA / genetics*
  • RNA / metabolism*
  • RNA, Long Noncoding / chemistry
  • RNA, Long Noncoding / genetics
  • RNA, Long Noncoding / metabolism
  • RNA, Messenger / chemistry
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Translational Research, Biomedical

Substances

  • RNA, Long Noncoding
  • RNA, Messenger
  • RNA-Binding Proteins
  • RNA
  • N-methyladenosine
  • Methyltransferases
  • Adenosine