cDNA cloning and amino acid sequence for human myelin-associated glycoprotein

Biochem Biophys Res Commun. 1989 Sep 29;163(3):1473-80. doi: 10.1016/0006-291x(89)91145-5.


cDNA clones of human myelin-associated glycoprotein were isolated and analyzed. The combination of the two overlapping cDNA clones covered the full coding region and the complete amino acid sequence was deduced. In rat and mouse, expression of the two forms of mRNA is developmentally regulated; the mRNA without exon 12 portion is expressed mainly in the actively myelinating stage of development. Although the cDNA library used here was prepared from adult human brain poly(A)+ RNA, all five clones obtained corresponded to the mRNA without exon 12 portion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Brain / metabolism
  • Cattle
  • Cloning, Molecular
  • DNA / genetics*
  • Humans
  • Mice
  • Molecular Sequence Data
  • Myelin Proteins / genetics*
  • Myelin-Associated Glycoprotein
  • RNA, Messenger / genetics
  • Restriction Mapping


  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • RNA, Messenger
  • DNA

Associated data

  • GENBANK/M29273