Alopecia universalis during treatment with leflunomide and adalimumab - case report

An Bras Dermatol. 2014 Mar-Apr;89(2):320-2. doi: 10.1590/abd1806-4841.20142944.


Alopecia areata is a non-scarring form of alopecia that can be localized or widespread. Its etiology is unknown, but immunological factors are implicated in its pathogenesis. With the more frequent use of anti TNFα biologic drugs, some alopecia areata cases during their use have been described. We report a case of universal alopecia in a patient with rheumatoid arthritis while using adalimumab and leflunomide.

Publication types

  • Case Reports

MeSH terms

  • Adalimumab
  • Aged
  • Alopecia / chemically induced*
  • Alopecia / pathology
  • Antibodies, Monoclonal, Humanized / adverse effects*
  • Antirheumatic Agents / adverse effects*
  • Arthritis, Rheumatoid / drug therapy*
  • Dermoscopy
  • Female
  • Humans
  • Isoxazoles / adverse effects*
  • Leflunomide
  • Skin / pathology
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors


  • Antibodies, Monoclonal, Humanized
  • Antirheumatic Agents
  • Isoxazoles
  • Tumor Necrosis Factor-alpha
  • Adalimumab
  • Leflunomide

Supplementary concepts

  • Alopecia universalis