The effect of arsenic on some antioxidant enzyme activities and lipid peroxidation in various tissues of mirror carp (Cyprinus carpio carpio)

Environ Sci Pollut Res Int. 2015 Mar;22(5):3212-8. doi: 10.1007/s11356-014-2896-6. Epub 2014 Apr 27.


The effect of arsenic bioaccumulation in liver, kidney, skin, muscle, and intestinal tissues of mirror carp (Cyprinus carpio carpio) was investigated on lipid peroxidation and certain antioxidant enzyme activities. In this study, three aquarium groups were formed from mirror carp: control group, 0.5-, and 1-mg/L arsenic concentrations. The fish were dissected after 1 month. Arsenic bioaccumulation, malondialdehyde (MDA) levels, catalase (CAT), and superoxide dismutase (SOD) enzyme activities were determined in the tissues. Results showed that arsenic was accumulated in liver, kidney, muscle, skin, and intestinal tissues. As the final product of lipid peroxidation, MDA levels were determined to have increased in all tissues with the exception of muscle. On the other hand, CAT and SOD enzyme activities in the fish tissues were decreased as compared to the control group. In the muscle tissue, differences were observed in the enzyme activities depending on arsenic concentration. Considering the increases in enzyme inhibition and MDA levels, liver was observed to be the main tissue affected in response to the arsenic toxicity.

MeSH terms

  • Animals
  • Arsenic / pharmacokinetics
  • Arsenic / toxicity*
  • Carps / metabolism*
  • Catalase / metabolism
  • Intestinal Mucosa / metabolism
  • Kidney / metabolism
  • Lipid Peroxidation / drug effects
  • Liver / metabolism
  • Malondialdehyde / metabolism
  • Muscles / metabolism
  • Skin / metabolism
  • Superoxide Dismutase / metabolism
  • Water Pollutants, Chemical / pharmacokinetics
  • Water Pollutants, Chemical / toxicity*


  • Water Pollutants, Chemical
  • Malondialdehyde
  • Catalase
  • Superoxide Dismutase
  • Arsenic