Salivary mucoepidermoid carcinoma revisited

Eur Arch Otorhinolaryngol. 2015 Apr;272(4):799-819. doi: 10.1007/s00405-014-3053-z. Epub 2014 Apr 26.


Clinicopathological features, prognosis and therapeutic strategies for mucoepidermoid carcinoma originating in salivary and salivary-type glands of the head and neck are reviewed. We emphasise histopathological aspects, appraise the value of histochemistry, electron microscopy, immunohistochemistry and cytophotometry, and discuss histogenesis and characteristic gene translocations. We additionally consider possible diagnostic difficulties, problems related to histological grading and accuracy of existing literature, and areas of controversy or uncertainty which may benefit from further investigations.

Publication types

  • Review

MeSH terms

  • Biopsy, Fine-Needle
  • Carcinoma, Mucoepidermoid* / genetics
  • Carcinoma, Mucoepidermoid* / pathology
  • Carcinoma, Mucoepidermoid* / therapy
  • Disease Management
  • Head and Neck Neoplasms* / genetics
  • Head and Neck Neoplasms* / pathology
  • Head and Neck Neoplasms* / therapy
  • Humans
  • Immunohistochemistry
  • Neoplasm Grading
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Prognosis
  • Salivary Gland Neoplasms* / genetics
  • Salivary Gland Neoplasms* / pathology
  • Salivary Gland Neoplasms* / therapy