Abstract
Myeloperoxidase (MPO) plays a central role in the innate immune system by generating leukocyte-derived oxidants to combat invading pathogens. These reactive intermediates have been increasingly recognized to be potentially deleterious, causing oxidative injury in inflammatory disease states such as cardiovascular disease. Recent evidence now suggests that circulating MPO can act as a clinical prognostic indicator for patients with cardiovascular disease.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Biomarkers / blood
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Case-Control Studies
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Coronary Artery Disease / blood*
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Coronary Artery Disease / diagnosis
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Coronary Artery Disease / mortality
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Coronary Artery Disease / physiopathology
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Free Radicals / metabolism
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Gene Expression
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Heart Failure / blood*
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Heart Failure / diagnosis
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Heart Failure / mortality
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Heart Failure / physiopathology
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Humans
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Immunity, Innate
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Peroxidase / genetics
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Peroxidase / metabolism*
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Plaque, Atherosclerotic / blood*
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Plaque, Atherosclerotic / diagnosis
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Plaque, Atherosclerotic / mortality
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Plaque, Atherosclerotic / physiopathology
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Prognosis
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Reactive Nitrogen Species / metabolism
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Reactive Oxygen Species / metabolism
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Survival Analysis
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Tyrosine / metabolism
Substances
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Biomarkers
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Free Radicals
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Reactive Nitrogen Species
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Reactive Oxygen Species
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tyrosine radical
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Tyrosine
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Peroxidase