Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Apr 28;13:38.
doi: 10.1186/1475-2891-13-38.

Immune-modulatory Effects of Dietary Yeast Beta-1,3/1,6-D-glucan

Free PMC article

Immune-modulatory Effects of Dietary Yeast Beta-1,3/1,6-D-glucan

Heike Stier et al. Nutr J. .
Free PMC article


Beta-glucans are a heterogeneous group of natural polysaccharides mostly investigated for their immunological effects. Due to the low systemic availability of oral preparations, it has been thought that only parenterally applied beta-glucans can modulate the immune system. However, several in vivo and in vitro investigations have revealed that orally applied beta-glucans also exert such effects. Various receptor interactions, explaining possible mode of actions, have been detected. The effects mainly depend on the source and structure of the beta-glucans. In the meantime, several human clinical trials with dietary insoluble yeast beta-glucans have been performed. The results confirm the previous findings of in vivo studies. The results of all studies taken together clearly indicate that oral intake of insoluble yeast beta-glucans is safe and has an immune strengthening effect.

Similar articles

See all similar articles

Cited by 17 articles

See all "Cited by" articles


    1. Pillemer L, Ecker EE. Anticomplementary factor in fresh yeast. J Biol Chem. 1941;137:139–142.
    1. Pillemer L, Schoenberg MD, Blum L, Wurz L. Properdin system and immunity. II. Interaction of the properdin system with polysaccharides. Science. 1955;122(3169):545–549. doi: 10.1126/science.122.3169.545. - DOI - PubMed
    1. Novak M, Vetvicka V. Beta-glucans, history, and the present: immunomodulatory aspects and mechanisms of action. J Immunotoxicol. 2008;5:47–57. doi: 10.1080/15476910802019045. - DOI - PubMed
    1. Novak M, Vetvicka V. Glucans as biological response modifiers. Endocr Metab Immune Disord Drug Targets. 2009;9:67–75. doi: 10.2174/187153009787582423. - DOI - PubMed
    1. Vetvicka V, Vetvickova J. beta1,3-glucan: silver bullet or hot air? Open Glycoscience. 2010;3:1–6.

Publication types

LinkOut - more resources