Olfactory exposure to males, including men, causes stress and related analgesia in rodents

Nat Methods. 2014 Jun;11(6):629-32. doi: 10.1038/nmeth.2935. Epub 2014 Apr 28.

Abstract

We found that exposure of mice and rats to male but not female experimenters produces pain inhibition. Male-related stimuli induced a robust physiological stress response that results in stress-induced analgesia. This effect could be replicated with T-shirts worn by men, bedding material from gonadally intact and unfamiliar male mammals, and presentation of compounds secreted from the human axilla. Experimenter sex can thus affect apparent baseline responses in behavioral testing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesia*
  • Animals
  • Female
  • Humans
  • Male
  • Mice
  • Olfactory Perception / physiology*
  • Pain / physiopathology*
  • Pain / psychology
  • Pain Measurement
  • Rats
  • Stress, Physiological*