'Lnc'-ing enhancers to MYC regulation

Cell Res. 2014 Jun;24(6):643-4. doi: 10.1038/cr.2014.54. Epub 2014 Apr 29.

Abstract

Long noncoding RNAs (lncRNAs) are emerging as important functional components in the establishment of long-range chromosomal interactions. In a recent paper published in Cell Research, Xiang et al. provide mechanistic insight into this phenomenon by characterizing the role of CCAT1-L, a colorectal cancer-specific lncRNA, in intra-chromosome looping between the MYC gene promoter and distal upstream enhancer elements that regulate MYC transcription.

Publication types

  • Comment

MeSH terms

  • Chromatin / metabolism*
  • Colorectal Neoplasms / genetics*
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Proto-Oncogene Proteins c-myc / genetics*
  • RNA, Long Noncoding / genetics*

Substances

  • Chromatin
  • Proto-Oncogene Proteins c-myc
  • RNA, Long Noncoding