What Is the Risk of Aluminium as a Neurotoxin?

Expert Rev Neurother. 2014 Jun;14(6):589-91. doi: 10.1586/14737175.2014.915745. Epub 2014 Apr 30.

Abstract

Aluminium is neurotoxic. Its free ion, Al(3+) (aq), is highly biologically reactive and uniquely equipped to do damage to essential cellular (neuronal) biochemistry. This unequivocal fact must be the starting point in examining the risk posed by aluminium as a neurotoxin in humans. Aluminium is present in the human brain and it accumulates with age. The most recent research demonstrates that a significant proportion of individuals older than 70 years of age have a potentially pathological accumulation of aluminium somewhere in their brain. What are the symptoms of chronic aluminium intoxication in humans? What if neurodegenerative diseases such as Alzheimer's disease are the manifestation of the risk of aluminium as a neurotoxin? How might such an (outrageous) hypothesis be tested?

Keywords: Alzheimer’s disease; aluminium; body burden; brain; neurotoxin.

Publication types

  • Editorial

MeSH terms

  • Aluminum / toxicity*
  • Alzheimer Disease / chemically induced*
  • Alzheimer Disease / pathology
  • Brain / pathology*
  • Humans

Substances

  • Aluminum