Diet and psoriasis, part II: celiac disease and role of a gluten-free diet

J Am Acad Dermatol. 2014 Aug;71(2):350-8. doi: 10.1016/j.jaad.2014.03.017. Epub 2014 Apr 26.


Patients with psoriasis have been shown to have a higher prevalence of other autoimmune diseases including celiac disease, a condition marked by sensitivity to dietary gluten. A number of studies suggest that psoriasis and celiac disease share common genetic and inflammatory pathways. Here we review the epidemiologic association between psoriasis and celiac disease and perform a meta-analysis to determine whether patients with psoriasis more frequently harbor serologic markers of celiac disease. We also examine whether a gluten-free diet can improve psoriatic skin disease.

Keywords: antigliadin; celiac disease; celiac sprue; diet; gluten-free; nutrition; psoriasis.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / blood
  • Celiac Disease / diet therapy*
  • Celiac Disease / epidemiology*
  • Celiac Disease / immunology
  • Diet, Gluten-Free*
  • GTP-Binding Proteins
  • Gliadin / immunology
  • Humans
  • Immunoglobulin A / blood*
  • Protein Glutamine gamma Glutamyltransferase 2
  • Psoriasis / diet therapy*
  • Psoriasis / epidemiology*
  • Psoriasis / immunology
  • Severity of Illness Index
  • Transglutaminases / immunology


  • Biomarkers
  • Immunoglobulin A
  • Gliadin
  • Protein Glutamine gamma Glutamyltransferase 2
  • Transglutaminases
  • GTP-Binding Proteins