Persistent and acute chlamydial infections induce different structural changes in the Golgi apparatus

Int J Med Microbiol. 2014 Jul;304(5-6):577-85. doi: 10.1016/j.ijmm.2014.03.002. Epub 2014 Apr 3.

Abstract

Chlamydia trachomatis causes a wide range of diseases that have a significant impact on public health. Acute chlamydial infections can cause fragmentation of the Golgi compartment ensuring the lipid transportation from the host cell. However, the changes that occur in the host cell Golgi apparatus after persistent infections are unclear. Here, we examined Golgi-associated gene (golga5) transcription and expression along with the structure of the Golgi apparatus in cells persistently infected with Chlamydia trachomatis. The results showed that persistent infections caused little fragmentation of the Golgi. The results also revealed that Golgi fragmentation might be associated with the suppression of transcription of the gene golga5.

Keywords: Acute infection; Chlamydia trachomatis; Golgi fragmentation; Persistent infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chlamydia trachomatis / growth & development*
  • Gene Expression
  • Golgi Apparatus / ultrastructure*
  • Golgi Matrix Proteins
  • HeLa Cells
  • Humans
  • Membrane Proteins / biosynthesis*
  • Vesicular Transport Proteins

Substances

  • GOLGA5 protein, human
  • Golgi Matrix Proteins
  • Membrane Proteins
  • Vesicular Transport Proteins