Cardiovascular responses to the ingestion of sugary drinks using a randomised cross-over study design: Does glucose attenuate the blood pressure-elevating effect of fructose?

Br J Nutr. 2014 Jul 28;112(2):183-92. doi: 10.1017/S0007114514000622. Epub 2014 Apr 29.


Overconsumption of sugar-sweetened beverages has been implicated in the pathogenesis of CVD. The objective of the present study was to elucidate acute haemodynamic and microcirculatory responses to the ingestion of sugary drinks made from sucrose, glucose or fructose at concentrations similar to those often found in commercial soft drinks. In a randomised cross-over study design, twelve young healthy human subjects (seven men) ingested 500 ml tap water in which was dissolved 60 g of either sucrose, glucose or fructose, or an amount of fructose equivalent to that present in sucrose (i.e. 30 g fructose). Continuous cardiovascular monitoring was performed for 30 min before and at 60 min after ingestion of sugary drinks, and measurements included beat-to-beat blood pressure (BP) and impedance cardiography. Additionally, microvascular endothelial function testing was performed after iontophoresis of acetylcholine and sodium nitroprusside using laser Doppler flowmetry. Ingestion of fructose (60 or 30 g) increased diastolic and mean BP to a greater extent than the ingestion of 60 g of either glucose or sucrose (P< 0.05). Ingestion of sucrose and glucose increased cardiac output (CO; P< 0.05), index of contractility (P< 0.05) and stroke volume (P< 0.05), but reduced total peripheral resistance (TPR; P< 0.05), which contrasts with the tendency of fructose (60 and 30 g) to increase resistance. Microvascular endothelial function did not differ in response to the ingestion of various sugary drinks. In conclusion, ingestion of fructose, but not sucrose, increases BP in healthy human subjects. Although sucrose comprises glucose and fructose, its changes in TPR and CO are more related to glucose than to fructose.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Carbonated Beverages / adverse effects*
  • Cardiac Output
  • Cross-Over Studies
  • Dietary Sucrose / adverse effects*
  • Dietary Sucrose / therapeutic use
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / physiology
  • Endothelium, Vascular / physiopathology
  • Female
  • Fructose / adverse effects*
  • Fructose / antagonists & inhibitors
  • Glucose / adverse effects
  • Hemodynamics* / drug effects
  • Humans
  • Male
  • Microvessels / drug effects
  • Microvessels / physiology
  • Microvessels / physiopathology
  • Myocardial Contraction
  • Prehypertension / etiology*
  • Prehypertension / physiopathology
  • Prehypertension / prevention & control
  • Stroke Volume
  • Vascular Resistance / drug effects
  • Vasoconstrictor Agents / pharmacology
  • Vasodilator Agents / pharmacology
  • Young Adult


  • Dietary Sucrose
  • Vasoconstrictor Agents
  • Vasodilator Agents
  • Fructose
  • Glucose