Genome reactivation after the silence in mitosis: recapitulating mechanisms of development?

Dev Cell. 2014 Apr 28;29(2):132-4. doi: 10.1016/j.devcel.2014.04.019.

Abstract

Transcription is silenced during mitosis and reactivated at mitotic exit. The dynamics and identities of "bookmarking" transcription factors and chromatin marks that mediate reactivation often recapitulate those observed during cell identity establishment in development. Thus, features of postmitotic gene reactivation can provide insights into mechanisms of developmental cell fate establishment.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Gene Expression Regulation, Developmental*
  • Genome / genetics*
  • Humans
  • Mitosis / genetics*
  • Transcription Factors / genetics*
  • Transcription, Genetic / genetics*

Substances

  • Transcription Factors