Early small vessel disease affects frontoparietal and cerebellar hubs in close correlation with clinical symptoms--a resting-state fMRI study

J Cereb Blood Flow Metab. 2014 Jul;34(7):1091-5. doi: 10.1038/jcbfm.2014.70. Epub 2014 Apr 30.


Cerebral small vessel disease, mainly characterized by white matter lesions and lacunes, has a high clinical impact as it leads to vascular dementia. Recent studies have shown that this disease impairs frontoparietal networks. Here, we apply resting-state magnetic resonance imaging and data-driven whole-brain imaging analysis methods (eigenvector centrality) to investigate changes of the functional connectome in early small vessel disease. We show reduced connectivity in frontoparietal networks, whereas connectivity increases in the cerebellum. These functional changes are closely related to white matter lesions and typical neuropsychological deficits associated with small vessel disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / blood supply
  • Brain / pathology
  • Brain / physiopathology*
  • Brain Mapping
  • Cerebrovascular Disorders / pathology
  • Cerebrovascular Disorders / physiopathology*
  • Female
  • Humans
  • Image Interpretation, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Neural Pathways / pathology
  • Neural Pathways / physiopathology*