Microvascular obstruction in patients with non-ST-elevation myocardial infarction: a contrast-enhanced cardiac magnetic resonance study

Int J Cardiovasc Imaging. 2014 Aug;30(6):1087-95. doi: 10.1007/s10554-014-0430-z. Epub 2014 Apr 30.


The aim of the study was to assess the frequency and predictive factors of microvascular obstruction (MVO) in patients with non-ST-segment elevation myocardial infarction (NSTEMI). This study included 190 consecutive patients with NSTEMI who underwent percutaneous coronary intervention (PCI) within 24 h after admission and cardiac magnetic resonance (CMR) imaging, 4.1 days after angiography. MVO was defined using the CMR criteria. MVO was detected 26 of 190 patients (13.8%). Patients with MVO had higher peak high-sensitivity troponin T, creatine-kinase and creatine kinase-myocardial band levels and higher proportions of those with baseline thrombolysis in myocardial infarction (TIMI) flow grade 0-1, absence of collateral circulation, post-PCI TIMI flow grade <3, myocardial blush grade <3 and angiographic no-reflow than patients without MVO. Patients with MVO had larger initial area at risk [median (25th-75th percentiles), 23.9% (17.4-33.9%) vs. 16.1% (7.8-27.7%), P = 0.018] and infarct size [11.4% (6.6-19.2%) vs. 1.4% (0-4.7%) of the left ventricle, P < 0.001] than patients without MVO. In multivariable analysis, the culprit lesion localization in the circumflex coronary artery [adjusted odds ratio (OR) 13.71, 95% confidence interval 2.91-64.58, P < 0.001] and the infarct size [adjusted OR 3.37 (1.80-6.29), P < 0.001, for each 5% of the left ventricle] were independently associated with the increased risk for MVO. In patients with NSTEMI undergoing early PCI, the MVO defined by CMR imaging was present in 13.8 % of the patients. The localization of culprit lesion in the circumflex coronary artery and larger infarct size were independently associated with the increased risk for MVO.

MeSH terms

  • Aged
  • Biomarkers / blood
  • Chi-Square Distribution
  • Contrast Media*
  • Coronary Angiography
  • Coronary Circulation*
  • Creatine Kinase, MB Form / blood
  • Female
  • Gadolinium DTPA*
  • Humans
  • Logistic Models
  • Magnetic Resonance Imaging*
  • Male
  • Microcirculation*
  • Middle Aged
  • Multivariate Analysis
  • Myocardial Infarction / blood
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / physiopathology
  • Myocardial Infarction / therapy*
  • No-Reflow Phenomenon / diagnosis*
  • No-Reflow Phenomenon / etiology
  • No-Reflow Phenomenon / physiopathology
  • Odds Ratio
  • Percutaneous Coronary Intervention / adverse effects*
  • Predictive Value of Tests
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • Troponin T / blood


  • Biomarkers
  • Contrast Media
  • Troponin T
  • Creatine Kinase, MB Form
  • Gadolinium DTPA