Inflammatory and immunomodulatory roles of TGF-beta

Immunol Today. 1989 Aug;10(8):258-61. doi: 10.1016/0167-5699(89)90136-9.

Abstract

Transforming growth factors (TGFs) are small polypeptides that were initially defined by their ability to induce transformation of non-neoplastic cells in culture. However, it has become increasingly clear that TGFs are not restricted in function to promoting cell growth. One type of transforming growth factor, TGF-beta, is a multifunctional molecule which has unique and potent effects on many target cells and tissues. In this article, Sharon Wahl, Nancy McCartney-Francis and Stephan Mergenhagen focus on the evolving role of TGF-beta in regulating inflammation, immune responses and tissue repair.

MeSH terms

  • Animals
  • Inflammation / etiology
  • Mice
  • Neovascularization, Pathologic
  • Transforming Growth Factors / immunology*

Substances

  • Transforming Growth Factors