Abstract
Three new isoflavanones (1-3) and thirteen known compounds (4-16) were isolated from the roots of Mucuna pruriens. The absolute configurations of isoflavanones 1-3 and parvisoflavanone (4), lespedeol C (5), and uncinanone C (6) were addressed by a circular dichroism technique. Isoflavanones, isoflavones, and pterocarpans of M. pruriens were found to be α-glucosidase inhibitors. Medicarpin (7) and parvisoflavone B (9) were potent α-glucosidase inhibitors (twofold less active than the standard drug acarbose). The production of bioactive metabolites in M. pruriens seems to be season-dependent.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line
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Cell Survival
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Glycoside Hydrolase Inhibitors / chemistry
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Glycoside Hydrolase Inhibitors / isolation & purification
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Glycoside Hydrolase Inhibitors / pharmacology*
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Humans
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Isoflavones / chemistry
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Isoflavones / isolation & purification
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Isoflavones / pharmacology*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Mucuna / chemistry*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Roots / chemistry
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Plants, Medicinal
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Pterocarpans / chemistry
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Pterocarpans / isolation & purification
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Pterocarpans / pharmacology*
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Seasons
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alpha-Glucosidases / drug effects*
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alpha-Glucosidases / metabolism
Substances
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Glycoside Hydrolase Inhibitors
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Isoflavones
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Plant Extracts
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Pterocarpans
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isoflavanone
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alpha-Glucosidases