Effect of antioxidants supplementation on aging and longevity

Biomed Res Int. 2014:2014:404680. doi: 10.1155/2014/404680. Epub 2014 Mar 25.


If aging is due to or contributed by free radical reactions, as postulated by the free radical theory of aging, lifespan of organisms should be extended by administration of exogenous antioxidants. This paper reviews data on model organisms concerning the effects of exogenous antioxidants (antioxidant vitamins, lipoic acid, coenzyme Q, melatonin, resveratrol, curcumin, other polyphenols, and synthetic antioxidants including antioxidant nanoparticles) on the lifespan of model organisms. Mechanisms of effects of antioxidants, often due to indirect antioxidant action or to action not related to the antioxidant properties of the compounds administered, are discussed. The legitimacy of antioxidant supplementation in human is considered.

Publication types

  • Review

MeSH terms

  • Aging / drug effects*
  • Aging / physiology*
  • Antioxidants / administration & dosage*
  • Dietary Supplements*
  • Evidence-Based Medicine
  • Humans
  • Longevity / drug effects*
  • Longevity / physiology*
  • Oxidative Stress / drug effects
  • Oxidative Stress / physiology
  • Reactive Oxygen Species / metabolism*
  • Treatment Outcome


  • Antioxidants
  • Reactive Oxygen Species