Circumscribed choroidal hemangioma associated with choroidal neovascularization in a HIV-infected case: photodynamic therapy and intravitreous ranibizumab

Photodiagnosis Photodyn Ther. 2014 Sep;11(3):441-3. doi: 10.1016/j.pdpdt.2014.04.005. Epub 2014 Apr 28.

Abstract

Circumscribed choroidal hemangioma (CCH) is rarely associated with choroidal neovascularization (CNV), especially in HIV-infected patients. And the therapy is still controversial. In this study, we discussed the mechanism, clinical feature and treatment of such lesions, based on multi-modality imaging evidences. Photodynamic therapy (PDT) might aggravate CNV as a side effect, and we concluded that intravitreal ranibizumab could be suggested as an effective therapy.

Keywords: Choroidal neovascularization; Circumscribed choroidal hemangioma; Enhanced depth imaging optical coherence tomography; HIV; Photodynamic therapy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage
  • Antibodies, Monoclonal, Humanized / administration & dosage*
  • Antineoplastic Agents / administration & dosage
  • Choroid Neoplasms / complications
  • Choroid Neoplasms / drug therapy*
  • Choroid Neoplasms / pathology
  • Choroidal Neovascularization / complications
  • Choroidal Neovascularization / drug therapy*
  • Choroidal Neovascularization / pathology
  • Drug Therapy, Combination / methods
  • Female
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • HIV Infections / pathology
  • Hemangioma / complications
  • Hemangioma / drug therapy*
  • Hemangioma / pathology
  • Humans
  • Intravitreal Injections
  • Middle Aged
  • Photochemotherapy / methods*
  • Photosensitizing Agents / administration & dosage
  • Ranibizumab
  • Treatment Outcome

Substances

  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents
  • Photosensitizing Agents
  • Ranibizumab