Effects of six months of vitamin D supplementation in patients with heart failure: a randomized double-blind controlled trial

Nutr Metab Cardiovasc Dis. 2014 Aug;24(8):861-8. doi: 10.1016/j.numecd.2014.02.015. Epub 2014 Mar 5.


Background and aim: Low plasma vitamin D levels have been associated with heart failure (HF). This research attempts to explain the role of vitamin D supplementation on myocardial function in elderly patients with HF.

Methods and results: Twenty-three chronic HF patients were randomized in a small parallel group, double-blind, placebo-controlled trial. All patients, with a mean age of 74 years and vitamin D levels <30 ng/mL, received 800,000 IU (4000 IU/daily) of cholecalciferol or placebo for 6 months. The outcomes measured at baseline and after 6 months were ejection fraction (EF) and other echocardiography parameters, carboxyterminal propeptide of procollagen type I (PIP), natriuretic peptides, lipid profile, renin, parathyroid hormone, blood pressure, and body mass index (BMI). In 13 patients under active treatment for 6 months, mean plasma 25-hydroxy vitamin D concentrations (15.51 vs. -1.40 ng/mL, p < 0.001) and plasma calcium (from 9.3 to 9.6 mmol/L, p < 0.05) increased significantly. However, other biomarkers of bone metabolism did not differ between the treatment and placebo groups. EF increased significantly in the intervention group (6.71 vs. -4.3%; p < 0.001), and the serum concentration of PIP increased only in the placebo group after 6 months (1140.98 vs. -145 mcg/L; p < 0.05). Systolic blood pressure was lower after 6 months of cholecalciferol treatment (from 129.6 to 122.7 mm Hg, p < 0.05). No significant variations were observed for other parameters.

Conclusions: Six months of vitamin D supplementation significantly improves EF in elderly patients with HF and vitamin D deficiency.

Keywords: Ejection fraction; Heart failure; Vitamin D supplements.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Blood Pressure
  • Body Mass Index
  • Calcium / blood
  • Cholecalciferol / blood
  • Cholecalciferol / therapeutic use
  • Collagen Type I / blood
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Heart Failure / drug therapy*
  • Humans
  • Male
  • Middle Aged
  • Parathyroid Hormone / blood
  • Renin / blood
  • Treatment Outcome
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D / therapeutic use
  • Vitamin D Deficiency / drug therapy


  • Biomarkers
  • Collagen Type I
  • Parathyroid Hormone
  • Vitamin D
  • Cholecalciferol
  • 25-hydroxyvitamin D
  • Renin
  • Calcium