Abstract
Vascular effects of 4-aryl methoxypiperidinol compounds previously shown to share with cocaine the ability to inhibit the dopamine transporter are described. All the compounds tested inhibit KCl-induced and noradrenaline-dependent contractions in mesenteric arteries ex vivo. Thus, diphenylpyraline and its analogs may have a role as therapeutic options for the treatment of some of the cardiotoxic effects of cocaine intoxications.
Keywords:
Arterial contraction; Dopamine transporter; Piperidinol-4.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Benzhydryl Compounds / chemical synthesis
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Benzhydryl Compounds / chemistry
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Benzhydryl Compounds / pharmacology*
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Dopamine Uptake Inhibitors / chemical synthesis
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Dopamine Uptake Inhibitors / chemistry
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Dopamine Uptake Inhibitors / pharmacology*
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Dose-Response Relationship, Drug
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Mesenteric Arteries / drug effects*
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Molecular Structure
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Muscle, Smooth, Vascular / drug effects*
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Norepinephrine / antagonists & inhibitors
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Norepinephrine / pharmacology
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Piperidines / chemical synthesis
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Piperidines / chemistry
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Piperidines / pharmacology*
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Potassium Chloride / antagonists & inhibitors
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Potassium Chloride / pharmacology
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Rats
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Structure-Activity Relationship
Substances
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Benzhydryl Compounds
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Dopamine Uptake Inhibitors
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Piperidines
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Potassium Chloride
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Norepinephrine