Vascular effects of diphenylmethoxypiperidine-derived dopamine uptake inhibitors

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2429-32. doi: 10.1016/j.bmcl.2014.04.040. Epub 2014 Apr 18.

Abstract

Vascular effects of 4-aryl methoxypiperidinol compounds previously shown to share with cocaine the ability to inhibit the dopamine transporter are described. All the compounds tested inhibit KCl-induced and noradrenaline-dependent contractions in mesenteric arteries ex vivo. Thus, diphenylpyraline and its analogs may have a role as therapeutic options for the treatment of some of the cardiotoxic effects of cocaine intoxications.

Keywords: Arterial contraction; Dopamine transporter; Piperidinol-4.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Benzhydryl Compounds / chemical synthesis
  • Benzhydryl Compounds / chemistry
  • Benzhydryl Compounds / pharmacology*
  • Dopamine Uptake Inhibitors / chemical synthesis
  • Dopamine Uptake Inhibitors / chemistry
  • Dopamine Uptake Inhibitors / pharmacology*
  • Dose-Response Relationship, Drug
  • Mesenteric Arteries / drug effects*
  • Molecular Structure
  • Muscle, Smooth, Vascular / drug effects*
  • Norepinephrine / antagonists & inhibitors
  • Norepinephrine / pharmacology
  • Piperidines / chemical synthesis
  • Piperidines / chemistry
  • Piperidines / pharmacology*
  • Potassium Chloride / antagonists & inhibitors
  • Potassium Chloride / pharmacology
  • Rats
  • Structure-Activity Relationship

Substances

  • Benzhydryl Compounds
  • Dopamine Uptake Inhibitors
  • Piperidines
  • Potassium Chloride
  • Norepinephrine