Effect of enterosorption on animal lifespan

Biomater Artif Cells Artif Organs. 1989;17(3):341-51. doi: 10.3109/10731198909118290.


Experiments were performed on Wistar male rats, starting from the 28th month of age. The effect of dietary sorbent (non coated nitrogen-containing carbon administered as 10 day courses at 1 month intervals in dosage of 10 ml/kg) on lifespan and a number of biological indices were studied. Enterosorption resulted in the increase of mean and maximal lifespan by 43 and 34% respectively. Analysis of the effect of enterosorption on activity of microsomal enzymes, intensity of total RNA and protein biosynthesis, lipid metabolism, formation of free radicals etc. showed that it produced a positive influence on the functional state of the studied systems and increased the organism's adaptive capacities. Enterosorption was found to delay the rate of onset of age-related structural changes in the organs and tissues.

MeSH terms

  • Aging / drug effects
  • Animals
  • Charcoal / pharmacology*
  • Lipid Metabolism
  • Liver / drug effects
  • Liver / enzymology
  • Liver / ultrastructure
  • Longevity / drug effects*
  • Male
  • Myocardium / cytology
  • Myocardium / ultrastructure
  • Protein Biosynthesis
  • RNA / biosynthesis
  • Rats
  • Rats, Inbred Strains


  • SKN hemosorbents
  • Charcoal
  • RNA