Profiles Drug Subst Excip Relat Methodol. 2014;39:113-204. doi: 10.1016/B978-0-12-800173-8.00003-9.


Curcumin and its two related compounds, that is, demethoxycurcumin and bis-demethoxycurcumin (curcuminoids) are the main secondary metabolites of Curcuma longa and other Curcuma spp. Curcumin is commonly used as coloring agent as well as food additive; curcumin has also shown some therapeutic activities. This review summarizes stability of curcumin in solutions, spectroscopy characteristics of curcumin (UV, IR, Raman, MS, and NMR), polymorphism forms, method of analysis in both of biological and nonbiological samples, and metabolite studies of curcumin. For analysis of curcumin and its related compounds in complex matrices, application of LC-MS/MS is recommended.

Keywords: Analysis; Chromatography; Curcuma spp.; Curcumin; Metabolism; Polymorphism; Spectroscopy; Stability.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Assay
  • Biological Availability
  • Chromatography, High Pressure Liquid
  • Curcumin / analysis*
  • Curcumin / chemistry*
  • Curcumin / pharmacokinetics
  • Curcumin / pharmacology
  • Drug Stability
  • Electrophoresis, Capillary
  • Food Additives / analysis*
  • Food Additives / chemistry*
  • Food Additives / pharmacokinetics
  • Food Additives / pharmacology
  • Humans
  • Limit of Detection
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Solubility


  • Food Additives
  • Curcumin