Transcriptional coregulators: fine-tuning metabolism

Cell Metab. 2014 Jul 1;20(1):26-40. doi: 10.1016/j.cmet.2014.03.027. Epub 2014 May 1.


Metabolic homeostasis requires that cellular energy levels are adapted to environmental cues. This adaptation is largely regulated at the transcriptional level, through the interaction between transcription factors, coregulators, and the basal transcriptional machinery. Coregulators, which function as both metabolic sensors and transcriptional effectors, are ideally positioned to synchronize metabolic pathways to environmental stimuli. The balance between inhibitory actions of corepressors and stimulatory effects of coactivators enables the fine-tuning of metabolic processes. This tight regulation opens therapeutic opportunities to manage metabolic dysfunction by directing the activity of cofactors toward specific transcription factors, pathways, or cells/tissues, thereby restoring whole-body metabolic homeostasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Energy Metabolism*
  • Histone Deacetylases / metabolism
  • Humans
  • Mitochondria / metabolism
  • Nuclear Receptor Coactivators / chemistry
  • Nuclear Receptor Coactivators / genetics
  • Nuclear Receptor Coactivators / metabolism*
  • Peroxisome Proliferator-Activated Receptors / metabolism
  • Retinoblastoma Protein / metabolism
  • Signal Transduction
  • Transcription Factors / chemistry
  • Transcription Factors / genetics
  • Transcription Factors / metabolism


  • Nuclear Receptor Coactivators
  • Peroxisome Proliferator-Activated Receptors
  • Retinoblastoma Protein
  • Transcription Factors
  • Histone Deacetylases