The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc

EMBO J. 1989 Oct;8(10):3095-103.

Abstract

The Drosophila segmentation gene, hairy (h), acts to regulate embryonic segmentation and bristle pattern. We present the DNA sequence of the h gene and of h cDNAs, thereby deducing the organization of the h transcripts. The h gene encodes a 337 amino acid protein that acts in both embryonic segmentation and adult bristle patterning. The h protein includes a domain that shows extensive similarity to a domain of the proto-oncogene N-myc that may be involved in DNA binding and/or protein dimerization. We discuss mechanisms of h action as a transcriptional regulator.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Basic Helix-Loop-Helix Transcription Factors
  • Blotting, Northern
  • Cosmids
  • DNA / genetics
  • Drosophila / genetics*
  • Drosophila Proteins*
  • Genes*
  • Insect Hormones
  • Insect Proteins*
  • Molecular Sequence Data
  • Mutation
  • Oncogenes*
  • Phenotype
  • RNA / genetics
  • Repressor Proteins*
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid
  • Transcription Factors / analysis
  • Transcription Factors / genetics*
  • Transcription Factors / physiology
  • Transcription, Genetic
  • Transfection

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • Drosophila Proteins
  • Insect Hormones
  • Insect Proteins
  • Repressor Proteins
  • Transcription Factors
  • hairy protein, Drosophila
  • hairy protein, insect
  • RNA
  • DNA

Associated data

  • GENBANK/X15904
  • GENBANK/X15905