Damage to the default mode network disrupts autobiographical memory retrieval

Soc Cogn Affect Neurosci. 2015 Mar;10(3):318-26. doi: 10.1093/scan/nsu070. Epub 2014 May 2.

Abstract

Functional neuroimaging studies have implicated the default mode network (DMN) in autobiographical memory (AM). Convergent evidence from a lesion approach would help clarify the role of the DMN in AM. In this study, we used a voxelwise lesion-deficit approach to test the hypothesis that regions of the DMN are necessary for AM. We also explored whether the neural correlates of semantic AM (SAM) and episodic AM (EAM) were overlapping or distinct. Using the Iowa Autobiographical Memory Questionnaire, we tested AM retrieval in 92 patients with focal, stable brain lesions. In support of our hypothesis, damage to regions within the DMN (medial prefrontal cortex, mPFC; posterior cingulate cortex, PCC; inferior parietal lobule, IPL; medial temporal lobe, MTL) was associated with AM impairments. Within areas of effective lesion coverage, the neural correlates of SAM and EAM were largely distinct, with limited areas of overlap in right IPL. Whereas SAM deficits were associated with left mPFC and MTL damage, EAM deficits were associated with right mPFC and MTL damage. These results provide novel neuropsychological evidence for the necessary role of parts of the DMN in AM. More broadly, the findings shed new light on how the DMN participates in self-referential processing.

Keywords: autobiographical memory retrieval; default mode network; episodic autobiographical memory; self-referential processing; semantic autobiographical memory.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Brain Damage, Chronic / physiopathology
  • Brain Damage, Chronic / psychology*
  • Brain Mapping
  • Female
  • Functional Laterality
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory, Episodic*
  • Mental Recall*
  • Middle Aged
  • Nerve Net / injuries*
  • Nerve Net / physiopathology
  • Neuropsychological Tests
  • Psychomotor Performance
  • Surveys and Questionnaires
  • Young Adult