Arylboronate ester based diazeniumdiolates (BORO/NO), a class of hydrogen peroxide inducible nitric oxide (NO) donors

Allimuthu T Dharmaraja; Govindan Ravikumar; Harinath Chakrapani

doi:10.1021/ol5010643

Arylboronate ester based diazeniumdiolates (BORO/NO), a class of hydrogen peroxide inducible nitric oxide (NO) donors

Org Lett. 2014 May 16;16(10):2610-3. doi: 10.1021/ol5010643. Epub 2014 May 5.

Authors

Allimuthu T Dharmaraja¹, Govindan Ravikumar, Harinath Chakrapani

Affiliation

¹ Indian Institute of Science Education and Research Pune, Dr. Homi Bhabha Road, Pashan, Pune 411 008, Maharashtra, India.

PMID: 24796212
DOI: 10.1021/ol5010643

Abstract

Here, we report the design, synthesis, and evaluation of arylboronate ester based diazeniumdiolates (BORO/NO), a class of nitric oxide (NO) donors activated by hydrogen peroxide (H2O2), a reactive oxygen species (ROS), to generate NO. We provide evidence for the NO donors' ability to permeate bacteria to produce NO when exposed to H2O2 supporting possible applications for BORO/NO to study molecular mechanisms of NO generation in response to elevated ROS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Azo Compounds / chemistry*
Boron Compounds / chemistry*
Hydrogen Peroxide / chemistry*
Molecular Structure
Nitric Oxide / chemical synthesis
Nitric Oxide / chemistry
Nitric Oxide Donors / chemical synthesis*
Nitric Oxide Donors / chemistry
Reactive Oxygen Species / chemistry

Substances

Azo Compounds
Boron Compounds
Nitric Oxide Donors
Reactive Oxygen Species
diazeniumdiolate
Nitric Oxide
Hydrogen Peroxide