Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells

Sci Rep. 2014 May 6;4:4693. doi: 10.1038/srep04693.


We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function relationship of intracellular organelles.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • COS Cells
  • Cell Line
  • Cell Membrane / metabolism*
  • Cell Membrane / physiology*
  • Chlorocebus aethiops
  • Nerve Tissue Proteins / metabolism*
  • Structure-Activity Relationship


  • Nerve Tissue Proteins
  • amphiphysin