Once-weekly exenatide as adjunct treatment of type 1 diabetes mellitus in patients receiving continuous subcutaneous insulin infusion therapy

Can J Diabetes. 2014 Aug;38(4):269-72. doi: 10.1016/j.jcjd.2013.10.006. Epub 2014 May 3.


Objective: The use of once-weekly exenatide in type 2 diabetes mellitus is well supported, but little is known about its effectiveness in type 1 diabetes. The objective of this study was to determine the clinical efficacy of once-weekly exenatide on glycemic control in patients with type 1 diabetes when added to basal-bolus insulin therapy.

Methods: For this retrospective study, patients with type 1 diabetes, aged 18 years and older, receiving continuous subcutaneous insulin infusion, using a continuous glucose monitoring device or regularly measuring blood glucose levels and receiving 2 mg of exenatide once weekly for at least 3 months were included. Demographic information, glycated hemoglobin (A1C), body weight, body mass index, systolic and diastolic blood pressures, total daily insulin dose, basal and bolus insulin doses, 28-day continuous subcutaneous insulin infusion glucose average and incidence of hypoglycemia were collected at baseline and 3 months after beginning therapy with once-weekly exenatide.

Results: An electronic medical record search identified 11 patients with type 1 diabetes who met the inclusion criteria. Comparing baseline and 3 months after initiation of once-weekly exenatide revealed reductions of 0.6% in A1C (p=0.013), 3.7% in body weight (p=0.008), 1.7 kg/m(2) in body mass index (p=0.003), 13% in total daily insulin dose (p=0.011) and 9.3 units in bolus insulin dose (p=0.015).

Conclusions: This study revealed that the addition of once-weekly exenatide to insulin therapy for type 1 diabetes patients leads to significant improvements in A1C, body weight, body mass index and insulin doses.

Keywords: GLP-1 (glucagon-like peptide-1); diabetes; diabète; exenatide; exénatide; glucagon-like peptide-1; incretin; incrétine.

MeSH terms

  • Adult
  • Body Mass Index
  • Diabetes Mellitus, Type 1 / drug therapy*
  • Exenatide
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Insulin / therapeutic use*
  • Insulin Infusion Systems
  • Peptides / therapeutic use*
  • Retrospective Studies
  • Venoms / therapeutic use*


  • Hypoglycemic Agents
  • Insulin
  • Peptides
  • Venoms
  • Exenatide