A Conceptual Framework for Research on Subjective Cognitive Decline in Preclinical Alzheimer's Disease

Alzheimers Dement. 2014 Nov;10(6):844-52. doi: 10.1016/j.jalz.2014.01.001. Epub 2014 May 3.

Abstract

There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.

Keywords: Alzheimer's disease; Mild cognitive impairment; Preclinical Alzheimer's disease; Prodromal Alzheimer 's disease; Research criteria; Subjective cognitive decline.

Publication types

  • Review

MeSH terms

  • Age of Onset
  • Alzheimer Disease / physiopathology*
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / physiopathology*
  • Disease Progression*
  • Female
  • Humans
  • Male
  • Neuropsychological Tests
  • Prodromal Symptoms*
  • Psychiatric Status Rating Scales
  • Terminology as Topic