The immune landscape of human tumors: Implications for cancer immunotherapy

Oncoimmunology. 2014 Jan 1;3(1):e27456. doi: 10.4161/onci.27456. Epub 2014 Jan 3.


Understanding the spontaneous immune response of cancer patients is critical for the design of efficient anticancer immunotherapies. The power of integrative tumor immunology approaches allowed for a comprehensive view of the immune system evolution in the course of tumor progression and recurrence. We have demonstrated that tumor-infiltrating immune cells are spatiotemporally regulated, a finding that has profound implications for the development of efficient anticancer immunotherapies.

Keywords: bioinformatics; cancer; immune landscape; immunoscore; prognosis.