Immunosurveillance of senescent cancer cells by natural killer cells

Oncoimmunology. 2014 Jan 1;3(1):e27616. doi: 10.4161/onci.27616. Epub 2014 Jan 6.


We recently dissected how senescent tumors can trigger complementing signaling pathways that mobilize natural killer (NK) cells to eliminate malignant cells. In addition to cell-intrinsic effects on proliferation, senescence induces the production of chemokine (C-C motif) ligand 2 (CCL2), which recruits NK cells to mediate direct tumoricidal effects. Hence, senescence activates a cancer cell-extrinsic oncosuppression program.

Keywords: NK cell; NKG2D; chemokine; p53; senescence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural