H2 unimolecular elimination in electrospray ionization mass spectrometry from erythraline, a spirocyclic alkaloid

Denise Brentan Silva; Thais Guaratini; Ricardo Vessecchi; Norberto Peporine Lopes; Benedikt Cramer; Hans-Ulrich Humpf; João Luis Callegari Lopes

doi:10.1255/ejms.1243

H2 unimolecular elimination in electrospray ionization mass spectrometry from erythraline, a spirocyclic alkaloid

Eur J Mass Spectrom (Chichester). 2013;19(5):345-50. doi: 10.1255/ejms.1243.

Authors

Denise Brentan Silva, Thais Guaratini, Ricardo Vessecchi, Norberto Peporine Lopes, Benedikt Cramer, Hans-Ulrich Humpf, João Luis Callegari Lopes

PMID: 24800418
DOI: 10.1255/ejms.1243

Abstract

Erythrina alkaloids, which contain a spirocyclic structure, are well known due to their important biological activity at the central nervous system. In this study, systematic electrospray ionization tandem mass spectrometry (ESI-MS/MS) and ESI-multistage mass spectrometry (MS(n)) analysis of erythraline have shown an unexpected H2 neutral elimination reaction. We have investigated the formation of these ions by accurate-mass ESI-MS/MS with different analyzers and the data suggest a possible unimolecular reaction of H2 loss.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Indole Alkaloids / chemistry*
Ions / chemistry*
Molecular Conformation
Spectrometry, Mass, Electrospray Ionization / methods*

Substances

Indole Alkaloids
Ions
erythraline