Post-translational modifications of tubulin

Curr Biol. 2014 May 5;24(9):R351-4. doi: 10.1016/j.cub.2014.03.032.


Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational modifications (PTMs) of tubulin as a potent mechanism to generate microtubule identities. As many microtubule functions have direct implications for development and homeostasis of organisms, understanding the molecular functions of tubulin PTMs could provide a more differentiated view on the role of microtubules in both normal and pathological aspects of organism development.

MeSH terms

  • Acetylation
  • Amination
  • Cell Division / physiology
  • Cell Movement / physiology
  • Cell Shape / physiology
  • Cytoskeleton / genetics
  • Cytoskeleton / physiology
  • Microtubules / metabolism*
  • Phosphorylation
  • Protein Processing, Post-Translational*
  • Tubulin / biosynthesis
  • Tubulin / genetics
  • Tubulin / metabolism*


  • Tubulin