Proton pump inhibitors and functional decline in older adults discharged from acute care hospitals

J Am Geriatr Soc. 2014 Jun;62(6):1110-5. doi: 10.1111/jgs.12826. Epub 2014 May 6.


Objectives: To investigate the relationship between use of proton pump inhibitors (PPIs) and incident dependency in older adults discharged from acute care hospitals.

Design: Prospective observational study.

Setting: Eleven geriatric and internal medicine acute care wards located throughout Italy.

Participants: Individuals (mean age 79.2 ± 5.5) who were not completely dependent at the time of discharge from participating wards (N = 401).

Measurements: The outcome of interest was the loss of at least one basic activity of daily living (ADL) from discharge to the end of follow-up (12 months). The relationship between PPI use and functional decline was investigated using logistic regression analysis before and after propensity score matching.

Results: Use of PPIs was significantly associated with functional decline before (odds ratio (OR) = 1.75, 95% confidence interval (CI) = 1.17-2.60) and after propensity score matching (OR = 2.44; 95% CI = 1.36-4.41). Other predictors of functional decline were hypoalbuminemia (OR = 3.10, 95% CI = 1.36-7.10 before matching, OR = 2.81, 95% CI = 1.09-7.77 after matching) and cognitive impairment (OR = 4.08, 95% CI = 1.63-10.2 before matching, OR = 6.35, 95% CI = 1.70-24.0 after matching).

Conclusion: Use of PPIs is associated with functional decline during 12 months of follow-up in older adults discharged from acute care hospitals.

Keywords: activities of daily living; elderly; functional decline; hospital; proton pump inhibitors.

Publication types

  • Multicenter Study
  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living*
  • Aged
  • Female
  • Humans
  • Male
  • Patient Discharge
  • Prospective Studies
  • Proton Pump Inhibitors / therapeutic use*


  • Proton Pump Inhibitors