Trias of keratosis pilaris, ulerythema ophryogenes and 18p monosomy: Zouboulis syndrome

J Dermatol. 2014 May;41(5):371-6. doi: 10.1111/1346-8138.12442.


Keratosis pilaris and ulerythema ophryogenes (keratosis pilaris atrophicans faciei) are part of a group of hereditary disorders of hair follicle keratinization involving follicular inflammation and subsequent atrophy. Monosomy 18p refers to a chromosomal disorder resulting from the deletion of all or part of the short arm of chromosome 18. This trias was first described in a patient by Zouboulis et al. (1994) and has been reported by different authors in four additional patients since then. We have reviewed the five almost identical cases that have been reported in 20 years and we suggest the existence of a new rare syndrome characterized by the trias keratosis pilaris, ulerythema ophryogenes and monosomy 18p. Recognition of the syndrome could assist in early diagnosis of monosomy 18p in these patients.

Keywords: 18p monosomy; Zouboulis syndrome; genodermatosis; hair follicle; keratosis pilaris; ulerythema.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Abnormalities, Multiple / genetics*
  • Abnormalities, Multiple / pathology
  • Adolescent
  • Adult
  • Chromosome Deletion
  • Chromosome Disorders / genetics*
  • Chromosome Disorders / pathology
  • Chromosomes, Human, Pair 18 / genetics
  • Darier Disease / genetics*
  • Darier Disease / pathology
  • Diagnosis, Differential
  • Eyebrows / abnormalities*
  • Eyebrows / pathology
  • Female
  • Humans
  • Laminin / deficiency
  • Laminin / genetics
  • Male
  • Syndrome
  • Young Adult


  • Laminin
  • laminin A

Supplementary concepts

  • Burnett Schwartz Berberian syndrome
  • Chromosome 18p deletion syndrome