Central motor conduction studies in motor neurone disease using magnetic brain stimulation

Electroencephalogr Clin Neurophysiol. Nov-Dec 1989;74(6):431-7. doi: 10.1016/0168-5597(89)90032-4.


Central motor conduction (CMC) to abductor digiti minimi (ADM) was evaluated in 22 patients with motor neurone disease (MND) using magnetic stimulation of the motor cortex and electrical stimulation at the C7/T1 interspace. CMC was abnormal in 14 patients; prolonged CMC time and absence of response to brain stimulation were more frequent abnormalities than low amplitude responses without prolonged CMC time. The technique can reveal subclinical upper motor neurone involvement and document central motor pathway dysfunction in MND. The patterns of abnormality are not specific to MND; all may occur in other neurological disorders including multiple sclerosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amyotrophic Lateral Sclerosis / physiopathology*
  • Central Nervous System / physiopathology*
  • Electric Stimulation
  • Hand / physiopathology
  • Humans
  • Magnetics*
  • Middle Aged
  • Motor Cortex / physiopathology*
  • Motor Neurons / physiology
  • Muscles / physiopathology
  • Neural Conduction / physiology*