Fluticasone propionate/formoterol fumarate in fixed-dose combination for the treatment of asthma

Expert Rev Respir Med. 2014 Jun;8(3):275-91. doi: 10.1586/17476348.2014.905914. Epub 2014 May 6.


A new combination inhaler containing fluticasone, a potent inhaled corticosteroid (ICS), and formoterol, a long-acting β-agonist (LABA) with rapid onset and sustained bronchodilator effect, has been approved for treatment of persistent asthma in patients ≥12 years of age requiring combination ICS-LABA therapy. The fluticasone/formoterol combination, delivered via pressurized metered-dose inhaler and available in three dose strengths, has demonstrated a good safety and tolerability profile in trials of up to 1 year. The efficacy of fluticasone/formoterol is greater than that of fluticasone or formoterol alone and noninferior to that of fluticasone/salmeterol and budesonide/formoterol in tightly controlled 8-12-week clinical trials. Advantages of the fluticasone/formoterol combination aerosol include rapid onset of bronchodilation, an attribute preferred by patients, and emission of a high fine-particle fraction that is consistent at different flow rates, which may aid consistency of delivery (given patient variability in inhalation maneuvers) and provide real-life benefits.

Keywords: anti-inflammatory; asthma; bronchodilator; fluticasone propionate; formoterol fumarate; inhaled corticosteroid; long-acting β-agonist.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage*
  • Adrenergic beta-2 Receptor Agonists / administration & dosage*
  • Aerosols
  • Androstadienes / administration & dosage*
  • Androstadienes / chemistry
  • Asthma / drug therapy*
  • Asthma / physiopathology
  • Bronchodilator Agents / administration & dosage*
  • Clinical Trials, Phase III as Topic
  • Drug Combinations
  • Ethanolamines / administration & dosage*
  • Fluticasone
  • Forced Expiratory Volume / drug effects
  • Formoterol Fumarate
  • Humans
  • Particle Size
  • Randomized Controlled Trials as Topic
  • Treatment Outcome


  • Adrenal Cortex Hormones
  • Adrenergic beta-2 Receptor Agonists
  • Aerosols
  • Androstadienes
  • Bronchodilator Agents
  • Drug Combinations
  • Ethanolamines
  • Fluticasone
  • Formoterol Fumarate